@prefix ex: <https://sparql.orthodb.org/.well-known/sparql-examples/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .
@prefix spex:<https://purl.expasy.org/sparql-examples/ontology#> .

ex:18 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Find zebrafish orthologs of disease-implicated (according to Nextprot SPARQL endpoint) human genes via Vertebrata-level orthogroup/s annotated with both IPR000719 (protein kinase domain) and GO:0048013 (ephrin receptor signaling pathway)"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX up: <http://purl.uniprot.org/core/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX GO: <http://purl.obolibrary.org/obo/GO_>
PREFIX : <http://purl.orthodb.org/>
PREFIX np: <http://nextprot.org/rdf#>
PREFIX interpro: <http://www.ebi.ac.uk/interpro/entry/>

SELECT ?gene_zf ?gene_zf_name ?gene ?gene_name ?description ?go ?disease
WHERE {
	SERVICE <https://sparql.nextprot.org/> {
        select distinct ?entry ?disease WHERE {
            ?entry np:isoform / np:disease / rdfs:comment ?disease
        }
    }
    ?gene rdfs:seeAlso ?entry;
        :name ?gene_name ;
        :description ?description.
    ?gene :memberOf ?og .
    ?og :xref/:xrefResource interpro:IPR000719 , GO:0048013.
    ?og :ogBuiltAt/up:scientificName "Vertebrata";
        :hasMember ?gene_zf.
    ?gene_zf :name ?gene_zf_name;
        up:organism/a [up:scientificName "Danio rerio"].
} ORDER BY ?disease
""" ;
    schema:target <https://sparql.orthodb.org/sparql/> ;
    spex:federatesWith <https://sparql.nextprot.org/> .