@prefix ex: .
@prefix rdfs: .
@prefix schema: .
@prefix sh: .
@prefix spex: .
ex:117_biosodafrontend_glioblastoma_orthologs_rat a sh:SPARQLExecutable,
sh:SPARQLSelectExecutable ;
rdfs:comment "Which are the proteins associated with glioblastoma and the orthologs expressed in the rat brain?"@en ;
sh:prefixes _:sparql_examples_prefixes ;
sh:select """PREFIX rdfs:
PREFIX obo:
PREFIX orth:
PREFIX sio:
PREFIX taxon:
PREFIX up:
PREFIX lscr:
PREFIX genex:
SELECT DISTINCT ?protein ?orthologous_protein ?gene ?annotation_text WHERE {
{
SELECT ?protein ?annotation_text WHERE {
?protein a up:Protein ;
up:organism taxon:9606 ;
up:annotation ?annotation .
?annotation rdfs:comment ?annotation_text .
?annotation a up:Disease_Annotation .
FILTER CONTAINS (?annotation_text, "glioblastoma")
}
}
SERVICE {
SELECT ?orthologous_protein ?protein ?gene WHERE {
?protein_OMA a orth:Protein .
?orthologous_protein a orth:Protein .
?cluster a orth:OrthologsCluster .
?cluster orth:hasHomologousMember ?node1 .
?cluster
orth:hasHomologousMember ?node2 .
?node2 orth:hasHomologousMember* ?protein_OMA .
?node1 orth:hasHomologousMember* ?orthologous_protein .
?orthologous_protein orth:organism/obo:RO_0002162 taxon:10116 . # rattus norvegicus
?orthologous_protein sio:SIO_010079 ?gene .
?protein_OMA lscr:xrefUniprot ?protein .
FILTER(?node1 != ?node2)
}
}
SERVICE {
?gene genex:isExpressedIn ?a .
?a rdfs:label "brain" .
?gene orth:organism ?s .
?s obo:RO_0002162 taxon:10116.
}
}""" ;
schema:target ;
spex:federatesWith , .