@prefix ex: <https://sparql.uniprot.org/.well-known/sparql-examples/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .
@prefix spex:<https://purl.expasy.org/sparql-examples/ontology#> .

ex:40 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Retrieve human enzymes that metabolize sphingolipids and are annotated in ChEMBL"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX CHEBI: <http://purl.obolibrary.org/obo/CHEBI_>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX rh: <http://rdf.rhea-db.org/>
PREFIX taxon: <http://purl.uniprot.org/taxonomy/>
PREFIX up: <http://purl.uniprot.org/core/>

SELECT DISTINCT ?protein ?chemblEntry
WHERE {
  SERVICE <https://sparql.rhea-db.org/sparql> {
    ?rhea rdfs:subClassOf rh:Reaction ;
      rh:side/rh:contains/rh:compound/rh:chebi/rdfs:subClassOf+ CHEBI:26739 .
  }
  ?ca up:catalyzedReaction ?rhea .
  ?protein up:annotation/up:catalyticActivity ?ca ;
    up:organism taxon:9606 ;
    rdfs:seeAlso ?chemblEntry .
  ?chemblEntry up:database <http://purl.uniprot.org/database/ChEMBL> .
}""" ;
    schema:keywords "enzyme" , "small molecule" , "cross-reference" , "ChEMBL" , "federated query" ;
    schema:target <https://sparql.uniprot.org/sparql/> ;
    spex:federatesWith <https://sparql.rhea-db.org/sparql> .