@prefix ex: <https://sparql.uniprot.org/.well-known/sparql-examples/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .
@prefix spex:<https://purl.expasy.org/sparql-examples/ontology#> .

ex:50 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment """Where are the human genes encoding enzymes metabolizing N-acyl
sphingosines expressed in the human body (federated query, with Rhea and Bgee)"""@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX CHEBI: <http://purl.obolibrary.org/obo/CHEBI_>
PREFIX genex: <http://purl.org/genex#>
PREFIX lscr: <http://purl.org/lscr#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX rh: <http://rdf.rhea-db.org/>
PREFIX taxon: <http://purl.uniprot.org/taxonomy/>
PREFIX up: <http://purl.uniprot.org/core/>

SELECT
  DISTINCT
    ?chebi
    ?reaction
    ?protein ?ensemblGene
    ?anatomicEntityLabel
    ?anatomicEntity
WHERE {
  SERVICE <https://sparql.rhea-db.org/sparql> {
    ?reaction rdfs:subClassOf rh:Reaction .
    ?reaction rh:equation ?reactionEquation .
    ?reaction rh:side ?reactionSide .
    ?reactionSide rh:contains ?participant .
    ?participant rh:compound ?compound .
    ?compound rh:chebi ?chebi .
    ?chebi rdfs:subClassOf* CHEBI:52639
}
  ?protein up:organism taxon:9606 .
  ?protein up:annotation ?a .
  ?a a up:Catalytic_Activity_Annotation .
  ?a up:catalyticActivity ?ca .
  ?ca up:catalyzedReaction ?reaction .
  ?protein rdfs:seeAlso / up:transcribedFrom ?ensemblGene .

  SERVICE  <https://www.bgee.org/sparql/> {
    ?gene genex:isExpressedIn ?anatomicEntity .
    ?gene lscr:xrefEnsemblGene ?ensemblGene .
    ?anatomicEntity rdfs:label ?anatomicEntityLabel .
  }
}""" ;
    schema:keywords "enzyme", "tissue specificity" , "federated query" , "Ensembl" , "Bgee" ,  "Rhea" ;
    schema:target <https://sparql.uniprot.org/sparql/> ;
    spex:federatesWith <https://sparql.rhea-db.org/sparql> , <https://www.bgee.org/sparql/> .