@prefix ex: <https://sparql.uniprot.org/.well-known/sparql-examples/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:63_diseases_involving_enzymes_located_in_mitochondrion a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Find (Human genetic) diseases that are thought to be related to Enzymes, known to be located in the Mitochondrion"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX taxon: <http://purl.uniprot.org/taxonomy/>
PREFIX up: <http://purl.uniprot.org/core/>

SELECT
  DISTINCT
    ?disease
WHERE {
  ?protein a up:Protein ;
  up:organism taxon:9606 ;
  up:annotation ?disease_annotation ,
                ?subcellularLocation .
  {
    ?protein up:enzyme [] .
  } UNION {
    ?protein up:annotation/a up:Catalytic_Activity_Annotation .
  }
  ?disease_annotation a up:Disease_Annotation ;
    up:disease ?disease .
  ?subcellularLocation a up:Subcellular_Location_Annotation ;
    up:locatedIn ?location .
  ?location up:cellularComponent ?component .
  ?component up:partOf* <http://purl.uniprot.org/locations/173> .
}""" ;
    schema:keywords "enzyme" , "disease" , "subcellular location" , "list" ;
    schema:target <https://sparql.uniprot.org/sparql/> .