@prefix ex:<https://purl.expasy.org/sparql-examples/neXtProt/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:NXQ_00048 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Proteins with at least one variant of the type \"C->X\" (Cys to anything else) that are linked to one or more diseases"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX : <http://nextprot.org/rdf/>
PREFIX nextprot_cv: <http://nextprot.org/rdf/terminology/>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

SELECT DISTINCT ?entry WHERE {
 {
	?entry :isoform ?iso.
	?iso :variant ?var.
	?var :disease ?_.
	?var :original "C"^^xsd:string.
 } UNION {
 ?entry :isoform ?iso .
	?iso :proteoform ?pf.
	?pf :difference ?var.
	?var :evidence / :negative false. # positive evidence
	?pf :diseaseRelatedVariant / :term nextprot_cv:ME_0000013 . # cause of disease
	?var :original "C"^^xsd:string.

 }
}""" ;
    schema:keywords "disease",
        "tutorial",
        "variant" ;
    schema:target <https://sparql.nextprot.org/sparql> .