@prefix ex:<https://purl.expasy.org/sparql-examples/neXtProt/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:NXQ_00082 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Proteins whose genes are on chromosome 21 that have \"gold\" variants not associated with a disease"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX : <http://nextprot.org/rdf/>
PREFIX nextprot_cv: <http://nextprot.org/rdf/terminology/>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

SELECT DISTINCT ?entry WHERE {
 ?entry :gene / :chromosome "21"^^xsd:string; :isoform / :variant ?variant.
 ?variant :evidence / :quality :GOLD.
 filter not exists { ?variant :disease ?disease. }
 filter ( not exists {
	?entry :isoform / :proteoform ?pf.
	?pf :difference ?variant.
	?variant :evidence / :negative false. # variant with positive evidence
	?pf :diseaseRelatedVariant / :term nextprot_cv:ME_0000013 . # variant is causing disease
 } )
}""" ;
    schema:keywords "chromosomal location",
        "disease",
        "quality",
        "tutorial",
        "variant" ;
    schema:target <https://sparql.nextprot.org/sparql> .