@prefix ex:<https://purl.expasy.org/sparql-examples/neXtProt/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:NXQ_00290 a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Proteins that are enzymes requiring the cofactor Ca(2+) and with a calcium binding site"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX : <http://nextprot.org/rdf/>
PREFIX CHEBI: <http://purl.obolibrary.org/obo/CHEBI_>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX skos: <http://www.w3.org/2004/02/skos/core#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

SELECT DISTINCT ?entry (str(?name) as ?prot_name) (str(?ec) as ?ecs) where

{ ?entry :recommendedName ?name_entity .
 ?name_entity a :ProteinName; rdfs:label ?name.
 ?entry :isoform ?iso.
 ?iso :enzymeClassification /rdfs:comment ?ec.
 ?iso :cofactor /:interactant /skos:exactMatch CHEBI:29108. # Ca(2+) cofactor
 ?iso :bindingSite /:interactant ?inter.
 ?inter :accession "CHEBI:29108"^^xsd:string # binding site interactant Ca(2+)
}
order by asc(?ec)""" ;
    schema:keywords "enzyme",
        "small molecule interaction",
        "tutorial" ;
    schema:target <https://sparql.nextprot.org/sparql> .